Article
IL10 Variant g.5311A Is Associated with Visceral Leishmaniasis in Indian Population.
PloS one - 1 Jan 2015
Mishra Anshuman, Nizamuddin Sheikh, Arekatla Geethika, Prakash Satya, Dewangan Hemlata, Dominic Abishai, Mishra Abhishek, Sudhakar Digumarthi V S, Parine Narasimha R, Tupperwar Nitin C, Thangaraj Kumarasamy
Abstract excerpt
BACKGROUND: Visceral leishmaniasis (VL) is a multifactorial disease, where the host genetics play a significant role in determining the disease outcome. The immunological role of anti-inflammatory cytokine, Interleukin 10 (IL10), has been well-documented in parasite infections and considered as a key regulatory cytokine for VL. Although VL patients in India display high level of IL10 in blood serum, no genetic...
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