Article
Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2008
Salhi Adnene, Rodrigues Virmondes, Santoro Ferrucio, Dessein Helia, Romano Audrey, Castellano Lucio Roberto, Sertorio Mathieu, Rafati Sima, Chevillard Christophe, Prata Aluisio, Alcaïs Alexandre, Argiro Laurent, Dessein Alain
Abstract excerpt
In populations exposed to Leishmania braziliensis, certain subjects develop skin ulcers, whereas others are naturally protected against cutaneous leishmaniasis. We have evaluated which cytokines are most crucial in the development of skin lesions. We found that active lesions occur in subjects with polarized Th2 or mixed Th1/Th2 responses, both associated with elevated IL-10 production. IL-10 was strongly...
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