Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells.

Inflammation - 1 Oct 2015

Li Shufeng, Ren Yanjun, Peng Dayong, Yuan Zhen, Shan Shiying, Sun Huaqiang, Yan Xinfeng, Xiao Hong, Li Guang, Song Haihan

Abstract excerpt

Osteoarthritis (OA) is the most common type of arthritis, in which T cell responses and cytokines may play critical roles in the development of the disease. TIM-3 may affect immune responses and is correlated with decreased expression of interferon gamma (INF-γ) in CD4+ T cells. In the current study, we investigated the association between polymorphisms in the TIM-3 gene and susceptibility to OA. Two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Genetic Variation

Share to Hepatitis A Virus Cellular Receptor 2

Share to Interferon-gamma

Share to Membrane Proteins

Share to Osteoarthritis

Source

Identifiers

PMID: 25937557
DOI: 10.1007/s10753-015-0164-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells.PMID 25937557Read ↗

T-cell immunoglobulin domain and mucin domain 3 polymorphism affects cytokine expression in different cells and is associated with increased susceptibility to knee osteoarthritis.Semantic proximity Read ↗

Tim-3 polymorphism downregulates gene expression and is involved in the susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.Semantic proximity Read ↗

The -1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population.Semantic proximity Read ↗

TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjectsSemantic proximity Read ↗

The +4259A>C polymorphism of TIM-3 but not -1637C>T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population.Semantic proximity Read ↗

Genetic variation and significant association of polymorphism rs7700944 G>A of TIM-4 gene with rheumatoid arthritis susceptibility in Chinese Han and Hui populations.Semantic proximity Read ↗

T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status.Semantic proximity Read ↗

TIM-1 rs41297579 G>A (-1454) and TIM-4 rs7700944 gene polymorphisms as possible risk factor for rheumatoid arthritis: relation to activity and severity.Semantic proximity Read ↗

The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population.Semantic proximity Read ↗

TIM-3 genetic variants and risk of Behçet disease in the Iranian population.Semantic proximity Read ↗

Association of TIM-3 with anterior uveitis and associated systemic immune diseases: a Mendelian randomization analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.