T-cell immunoglobulin domain and mucin domain 3 polymorphism affects cytokine expression in different cells and is associated with increased susceptibility to knee osteoarthritis.

Abstract excerpt

Osteoarthritis (OA) is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. In China, knee OA accounts for the majority of the OA cases. Elevated immune responses and proinflammatory cytokine expressions have been identified in OA patients. Tim-3 plays critical roles in down-regulating T cell responses. Here, we first examined the correlation...

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