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Article

Tim-3 polymorphism downregulates gene expression and is involved in the susceptibility to ankylosing spondylitis.

DNA and cell biology - 1 Oct 2014

Wang Mingfei, Ji Bin, Wang Jian, Cheng Xiangyu, Zhou Qiang, Zhou Junjie, Cao Chengfu, Guo Qunfeng

Abstract excerpt

Ankylosing spondylitis (AS) is a chronic inflammatory disorder primarily affecting the sacroiliac joints and the spine. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3) has been established as a negative regulatory molecule that plays a critical role in controlling inflammation. Studies have shown that polymorphisms in TIM-3 gene may be associated with inflammatory diseases. The current study...

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Identifiers

PMID: 24905803
DOI: 10.1089/dna.2014.2456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Tim-3 polymorphism downregulates gene expression and is involved in the susceptibility to ankylosing spondylitis.PMID 24905803Read ↗

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The +4259A>C polymorphism of TIM-3 but not -1637C>T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population.Semantic proximity Read ↗

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Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis.Semantic proximity Read ↗

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