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Article

The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.

Immunology letters - 15 Aug 2004

Chae Soo-Cheon, Park Young-Ran, Shim Seung-Cheol, Yoon Kyung-Sik, Chung Hun-Taeg

Abstract excerpt

The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of TIM family, TIM-3 is selectively expressed on the surface of differentiated Th1 cells. TIM-3 might have an important role in the induction of autoimmune diseases by regulating macrophage activation and interacts with TIM-3 ligand to regulate Th1 responses. In the present study, we...

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PMID: 15325803
DOI: 10.1016/j.imlet.2004.06.008

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.PMID 15325803Read ↗

The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population.Semantic proximity Read ↗

The -1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population.Semantic proximity Read ↗

The association of TIM-3 gene polymorphism with atopic disease in Korean population.Semantic proximity Read ↗

Molecular variations in Th1-specific cell surface gene Tim-3.Semantic proximity Read ↗

Genetic variation and significant association of polymorphism rs7700944 G>A of TIM-4 gene with rheumatoid arthritis susceptibility in Chinese Han and Hui populations.Semantic proximity Read ↗

The +4259A>C polymorphism of TIM-3 but not -1637C>T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population.Semantic proximity Read ↗

TIM-3 rs1036199 polymorphism increases susceptibility to autoimmune diseases: evidence based on 4200 subjectsSemantic proximity Read ↗

T-cell immunoglobulin domain and mucin domain 3 polymorphism affects cytokine expression in different cells and is associated with increased susceptibility to knee osteoarthritis.Semantic proximity Read ↗

T-cell immunoglobulin and mucin domain 3 genetic polymorphisms are associated with rheumatoid arthritis independent of a shared epitope status.Semantic proximity Read ↗

TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4+ T Cells.Semantic proximity Read ↗

Tim-3 polymorphism downregulates gene expression and is involved in the susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population.Semantic proximity Read ↗

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