Article
Association of variants in IL1B, TLR9, TREM1, IL10RA, and CD3G and Native American ancestry on malaria susceptibility in Colombian populations.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2021
Mario-Vásquez Jorge Eliécer, Naranjo-González Carlos Andrés, Montiel Jehidys, Zuluaga Lina M, Vásquez Ana M, Tobón-Castaño Alberto, Bedoya Gabriel, Segura Cesar
Abstract excerpt
Host genetics is an influencing factor in the manifestation of infectious diseases. In this study, the association of mild malaria with 28 variants in 16 genes previously reported in other populations and/or close to ancestry-informative markers (AIMs) selected was evaluated in an admixed 736 Colombian population sample. Additionally, the effect of genetic ancestry on phenotype expression was explored. For this...
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