Article
Incidences and Prognostic Impact of c-KIT, WT1, CEBPA, and CBL Mutations, and Mutations Associated With Epigenetic Modification in Core Binding Factor Acute Myeloid Leukemia: A Multicenter Study in a Korean Population.
Annals of laboratory medicine - 1 May 2015
Park Sang Hyuk, Lee Hyun Ji, Kim In-Suk, Kang Jeong-Eun, Lee Eun Yup, Kim Hyeoung-Joon, Kim Yeo-Kyeoung, Won Jong-Ho, Bang Soo Mee, Kim Hawk, Song Moo-Kon, Chung Joo Seop, Shin Ho-Jin
Abstract excerpt
BACKGROUND: To identify potential molecular prognostic markers in core binding factor (CBF) AML, we analyzed incidences and prognostic impacts of mutations in c-KIT, WT1, CEBPA, CBL, and a number of epigenetic genes in CBF AML. METHODS: Seventy one and 21 AML patients with t(8;21) and inv(16) were enrolled in this study, respectively. NPM1, CEBPA, c-KIT, IDH1/2, DNMT3A, EZH2, WT1, and CBL mutations were analyzed...
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