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Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia

7 Oct 2008

Abstract excerpt

PURPOSE OF REVIEW: Core-binding factor (CBF) acute myeloid leukemia (AML) is among the most common cytogenetic subtypes of AML, being detected in approximately 13% of adults with primary disease. Although CBF-AML is associated with a relatively favorable prognosis, only one-half of the patients are cured. Herein we review recent discoveries of genetic and epigenetic alterations in CBF-AML that may represent novel...

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PMID: 18841055
DOI: 10.1097/cco.0b013e32831369df

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