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Article

Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review.

Hematology/oncology and stem cell therapy - 1 Mar 2017

Ayatollahi Hossein, Shajiei Arezoo, Sadeghian Mohammad Hadi, Sheikhi Maryam, Yazdandoust Ehsan, Ghazanfarpour Masumeh, Shams Seyyede Fatemeh, Shakeri Sepideh

Abstract excerpt

OBJECTIVE/BACKGROUND: Acute myeloid leukemia (AML) is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results. t(8;21)(q22;q22) and inv(16)(p13;q22) form core binding factor-AML (CBF-AML). c-kit mutation activation occurs in 12.8-46.1% of adults with CBF leukemia. These mutations occur in 20-25% of t(8;21) and 30% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Share to Proto-Oncogene Proteins c-kit

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Identifiers

PMID: 27613372
DOI: 10.1016/j.hemonc.2016.08.005

Genes

KIT

Provenance

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