Article
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Blood - 19 May 2016
Duployez Nicolas, Marceau-Renaut Alice, Boissel Nicolas, Petit Arnaud, Bucci Maxime, Geffroy Sandrine, Lapillonne Hélène, Renneville Aline, Ragu Christine, Figeac Martin, Celli-Lebras Karine, Lacombe Catherine, Micol Jean-Baptiste, Abdel-Wahab Omar, Cornillet Pascale, Ifrah Norbert, Dombret Hervé, Leverger Guy, Jourdan Eric, Preudhomme Claude
Abstract excerpt
Acute myeloid leukemia (AML) with t(8;21) or inv(16) have been recognized as unique entities within AML and are usually reported together as core binding factor AML (CBF-AML). However, there is considerable clinical and biological heterogeneity within this group of diseases, and relapse incidence reaches up to 40%. Moreover, translocations involving CBFs are not sufficient to induce AML on its own and the full...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.