Article
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
PloS one - 1 Jan 2014
Shimamoto Akira, Kagawa Harunobu, Zensho Kazumasa, Sera Yukihiro, Kazuki Yasuhiro, Osaki Mitsuhiko, Oshimura Mitsuo, Ishigaki Yasuhito, Hamasaki Kanya, Kodama Yoshiaki, Yuasa Shinsuke, Fukuda Keiichi, Hirashima Kyotaro, Seimiya Hiroyuki, Koyama Hirofumi, Shimizu Takahiko, Takemoto Minoru, Yokote Koutaro, Goto Makoto, Tahara Hidetoshi
Abstract excerpt
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition. Mutations in WRN are responsible for the disease and cause telomere dysfunction, resulting in accelerated aging. Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripotent stem cells (iPSCs). In the present study, we describe the effects of...
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