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Article

Unique clonal relationship between T-cell acute lymphoblastic leukemia and subsequent Langerhans cell histiocytosis with TCR rearrangement and NOTCH1 mutation.

Genes, chromosomes & cancer - 1 Jul 2015

Yokokawa Yuichi, Taki Tomohiko, Chinen Yoshiaki, Kobayashi Satoru, Nagoshi Hisao, Akiyama Masaharu, Morimoto Akira, Ida Hiroyuki, Taniwaki Masafumi

Abstract excerpt

Acute lymphoblastic leukemia (ALL) occasionally develops before or after the onset of Langerhans cell histiocytosis (LCH). The mechanism of LCH developing after ALL remains unclear; thus the clonality of LCH developing during maintenance chemotherapy for T-cell ALL (T-ALL) was investigated. The T-ALL and LCH cells tested had the same T-cell receptor (TCR) gamma rearrangement. Mutation analysis of the NOTCH1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytosis

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

Identifiers

PMID: 25930743
DOI: 10.1002/gcc.22252

Genes

NOTCH1

Variants

Provenance

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