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Article

Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.

American journal of hematology - 1 Feb 2008

Rodig Scott J, Payne Ethan G, Degar Barbara A, Rollins Barrett, Feldman Andrew L, Jaffe Elaine S, Androkites Arlene, Silverman Lewis B, Longtine Janina A, Kutok Jeffery L, Fleming Mark D, Aster Jon C

Abstract excerpt

Langerhans cell histiocytosis (LCH) and related entities are neoplasms of unknown pathogenesis. Here, we describe studies assessing the role of NOTCH1 mutations in LCH, which were based on a case of fatal Langerhans cell tumor after T-cell acute lymphoblastic leukemia (T-ALL). Although the two ty...

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Source

Identifiers

PMID: 17874453
DOI: 10.1002/ajh.21044

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17874453-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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