Article
Late recurrence of childhood T-cell acute lymphoblastic leukemia frequently represents a second leukemia rather than a relapse: first evidence for genetic predisposition.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2011
Szczepanski Tomasz, van der Velden Vincent H J, Waanders Esmé, Kuiper Roland P, Van Vlierberghe Pieter, Gruhn Bernd, Eckert Cornelia, Panzer-Grümayer Renate, Basso Giuseppe, Cavé Hélène, Stadt Udo Zur, Campana Dario, Schrauder André, Sutton Rosemary, van Wering Elisabeth, Meijerink Jules P P, van Dongen Jacques J M
Abstract excerpt
PURPOSE: Relapse of childhood T-cell acute lymphoblastic leukemia (T-ALL) often occurs during treatment, but in some cases, leukemia re-emerges off therapy. On the basis of previous analyses of T-cell receptor (TCR) gene rearrangement patterns, we hypothesized that some late recurrences of T-ALL might in fact represent second leukemias. PATIENTS AND METHODS: In 22 patients with T-ALL who had late relapses (at...
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