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miR-21 and miR-145 cooperation in regulation of colon cancer stem cells

30 Apr 2015

Abstract excerpt

BACKGROUND: Acquired drug resistance is one of the major reasons for failing cancer therapies. Although the reasons are not fully understood, they may be related to the presence of cancer stem cells (CSCs). We have reported that chemo-resistant (CR) colon cancer cells, highly enriched in CSCs, exhibit a marked up-regulation of miR-21 and that down-regulation of this miR renders the CR cells more susceptible to...

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PMID: 25928322
DOI: 10.1186/s12943-015-0372-7

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