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Article

Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex

25 Jun 2019

Abstract excerpt

Background and Purpose Salinomycin is a well‐known inhibitor of human cancer stem cells ( CSCs ). However, the molecular mechanism(s) by which salinomycin targets colorectal CSCs is poorly understood. Here, we have investigated underlying antitumour mechanisms of salinomycin in colorectal cancer cells and three tumour models. Experimental Approach The inhibitory effect of salinomycin on the Wnt/β‐catenin pathway...

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PMID: 31236922
DOI: 10.1111/bph.14770

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