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Article

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer.

Molecular therapy : the journal of the American Society of Gene Therapy - 7 Mar 2018

Zhu Yun, Wang Cindy, Becker Scott A, Hurst Katie, Nogueira Lourdes M, Findlay Victoria J, Camp E Ramsay

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance and cancer stem cells (CSCs). However, EMT pathways have proven challenging to therapeutically target. MicroRNA 145 (miR-145) targets multiple stem cell transcription factors and its expression is inversely correlated with EMT. Therefore, we hypothesized that miR-145 represents a therapeutic target to reverse snail family...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29475734
DOI: 10.1016/j.ymthe.2017.12.023
PMCID: PMC5910672

Genes

SNAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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