Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression

24 Sept 2014

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) has been associated with poor treatment outcomes in various malignancies and is inversely associated with miRNA145 expression. Therefore, we hypothesized that SNAI2 (Slug) may mediate 5-fluorouracil (5FU) chemotherapy resistance through inhibition of miR145 in colorectal cancer and thus represents a novel therapeutic target to enhance current colorectal cancer treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related molecular mechanisms research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25249558
DOI: 10.1158/1535-7163.mct-14-0207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 RepressionPMID 25249558Read ↗

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer.Semantic proximity Read ↗

Restoring miR-145 overcome oxaliplatin resistance by targeting the ABCC1 gene and re-establishing drug-induced anti-cancer effects in colorectal cancerSemantic proximity Read ↗

<scp>MiR</scp>‐506 inhibits multiple targets in the epithelial‐to‐mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancerSemantic proximity Read ↗

Putative tumor suppressor miR‐145 inhibits colon cancer cell growth by targeting oncogene friend leukemia virus integration 1 geneSemantic proximity Read ↗

MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.Semantic proximity Read ↗

Development of gemcitabine-modified miR-15a as a novel, multimodal treatment strategy to overcome 5-FU and oxaliplatin resistance in colorectal cancerSemantic proximity Read ↗

Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer.Semantic proximity Read ↗

MicroRNA-145 Targets YES and STAT1 in Colon Cancer CellsSemantic proximity Read ↗

MiR-145 in cancer therapy resistance and sensitivity: A comprehensive review.Semantic proximity Read ↗

SIRT2, a direct target of miR‐212‐5p, suppresses the proliferation and metastasis of colorectal cancer cellsSemantic proximity Read ↗

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersSemantic proximity Read ↗

Downregulation of γ-Catenin by miR-195-5p Inhibits Colon Cancer Progression, Regulating Desmosome FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.