Article

Restoring miR-145 overcome oxaliplatin resistance by targeting the ABCC1 gene and re-establishing drug-induced anti-cancer effects in colorectal cancer

2022-06-08

Abstract excerpt

<title>Abstract</title> <p>Drug resistance limits the effectiveness of chemotherapy in colorectal cancer (CRC). Consequently, finding appropriate strategies for re-sensitizing chemo-resistant cells is crucial. Our present study aimed at taking advantage of chemotherapy and gene therapy by restoring microRNA-145 expression in oxaliplatin resistant CRC cells. Bioinformatic analysis of clinical colorectal cancer tis...

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Literature Corpus work: 52b0c008-28de-5b0d-89e9-7e5535f52d47
DOI: 10.21203/rs.3.rs-1702860/v1

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