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Article

Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.

PloS one - 1 Jan 2012

Han Mingli, Liu Manran, Wang Yimeng, Chen Xin, Xu Jianli, Sun Yan, Zhao Liuyang, Qu Hongbo, Fan Yuanming, Wu Chengyi

Abstract excerpt

BACKGROUND: Accumulating evidence suggested that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) characteristics, both of which contribute to tumor invasion and metastasis, are interrelated with miR-21. MiR-21 is one of the important microRNAs associated with tumor progression and metastasis, but the molecular mechanisms underlying EMT and CSC phenotype during miR-21 contributes to migration...

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Source

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Identifiers

PMID: 22761812
DOI: 10.1371/journal.pone.0039520
PMCID: PMC3382593

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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