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Article

Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei.

Scientific reports - 12 May 2021

Morita Kohtaro, Hatanaka Yuki, Ihashi Shunya, Asano Masahide, Miyamoto Kei, Matsumoto Kazuya

Abstract excerpt

Paternal genome reprogramming, such as protamine-histone exchange and global DNA demethylation, is crucial for the development of fertilised embryos. Previously, our study showed that one of histone arginine methylation, asymmetrically dimethylated histone H3R17 (H3R17me2a), is necessary for epigenetic reprogramming in the mouse paternal genome. However, roles of histone arginine methylation in reprogramming...

Topics

Animals
Biomarkers
Cell Nucleus
Epigenesis, Genetic
Fluorescent Antibody Technique
Gene Expression Regulation, Developmental
Histones
Male
Methylation
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Processing, Post-Translational

Protein-Arginine N-Methyltransferases

Transcriptional Activation

Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 33980975
DOI: 10.1038/s41598-021-89334-w
PMCID: PMC8115239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33980975-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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