Article
Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis.
BMC genomics - 1 Jan 2015
Zhang Lu, Kim Sang, Jia Gaoxiang, Buhmeida Abdelbaset, Dallol Ashraf, Wright Woodring E, Fornace Albert J, Al-Qahtani Mohammed, Shay Jerry W
Abstract excerpt
BACKGROUND: We have generated a series of isogenically derived immortalized human colonic epithelial cell (HCEC 1CT and HCEC 2CT) lines, including parental un-immortalized normal cell strains. The CDK4 and hTERT immortalized colonic epithelial cell line (HCEC 1CT) is initially karyotypically normal diploid and expresses a series of epithelial cell markers including stem cell markers. Under stressful tissue...
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