Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial Cells

1 Apr 2011

Abstract excerpt

Chromosomal instability leading to aneuploidy occurs in most sporadic colorectal cancers (CRCs) and is believed to be an early driving force in disease progression. Despite this observation, the cellular advantages conferred by these cytogenetic alterations are poorly understood. Here, we provide evidence that serum-free passage of originally diploid, immortalized human colonic epithelial cells (HCECs) gave rise...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21472139
DOI: 10.1593/neo.101580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial CellsPMID 21472139Read ↗

Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis.Semantic proximity Read ↗

Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumorsSemantic proximity Read ↗

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cellsSemantic proximity Read ↗

Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoidsSemantic proximity Read ↗

Karyotypic characterization of colorectal adenocarcinomasSemantic proximity Read ↗

Single chromosome gains can function as metastasis suppressors and metastasis promoters in colon cancerSemantic proximity Read ↗

Single-chromosome aneuploidy commonly functions as a tumor suppressorSemantic proximity Read ↗

Chromosomal Aneuploidy Affects the Global Proteome Equilibrium of Colorectal Cancer CellsSemantic proximity Read ↗

Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.Semantic proximity Read ↗

Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas.Semantic proximity Read ↗

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.Semantic proximity Read ↗

Clonal karyotypic abnormalities in colorectal adenomas: Clues to the early genetic events in the adenoma‐carcinoma sequenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.