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Article

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2015

Silver Matt J, Corbin Karen D, Hellenthal Garrett, da Costa Kerry-Ann, Dominguez-Salas Paula, Moore Sophie E, Owen Jennifer, Prentice Andrew M, Hennig Branwen J, Zeisel Steven H

Abstract excerpt

Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesis that 3 SNPs that increase dependence on dietary choline would be under negative selection pressure in settings...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MTHFD1 gene

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 25921832
DOI: 10.1096/fj.15-271056
PMCID: PMC4511208

Genes

CHDH
MTHFD1
PEMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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