Article
Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.
International journal of molecular sciences - 26 Jan 2017
Ganz Ariel B, Cohen Vanessa V, Swersky Camille C, Stover Julie, Vitiello Gerardo A, Lovesky Jessica, Chuang Jasmine C, Shields Kelsey, Fomin Vladislav G, Lopez Yusnier S, Mohan Sanjay, Ganti Anita, Carrier Bradley, Malysheva Olga V, Caudill Marie A
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in choline metabolizing genes are associated with disease risk and greater susceptibility to organ dysfunction under conditions of dietary choline restriction. However, the underlying metabolic signatures of these variants are not well characterized and it is unknown whether genotypic differences persist at recommended choline intakes. Thus, we sought to determine if common...
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