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Article

Common genetic polymorphisms affect the human requirement for the nutrient choline.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2006

da Costa Kerry-Ann, Kozyreva Olga G, Song Jiannan, Galanko Joseph A, Fischer Leslie M, Zeisel Steven H

Abstract excerpt

Humans eating diets deficient in the essential nutrient choline can develop organ dysfunction. We hypothesized that common single nucleotide polymorphisms (SNPs) in genes involved in choline metabolism influence the dietary requirement of this nutrient. Fifty-seven humans were fed a low choline diet until they developed organ dysfunction or for up to 42 days. We tested DNA SNPs for allelic association with...

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Identifiers

PMID: 16816108
DOI: 10.1096/fj.06-5734com
PMCID: PMC1574369

Genes

CHDH
PEMT
BHMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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