Article
Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not.
The American journal of clinical nutrition - 1 Jul 2007
Niculescu Mihai D, da Costa Kerry-Ann, Fischer Leslie M, Zeisel Steven H
Abstract excerpt
BACKGROUND: Some humans fed a low-choline diet develop hepatosteatosis, liver and muscle damage, and lymphocyte apoptosis. The risk of developing such organ dysfunction is increased by the presence of single-nucleotide polymorphisms (SNPs) in genes involved in folate and choline metabolism. OBJECTIVE: We investigated whether these changes that occur in the expression of many genes when humans are fed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.