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Article

High intakes of choline and betaine reduce breast cancer mortality in a population-based study.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2009

Xu Xinran, Gammon Marilie D, Zeisel Steven H, Bradshaw Patrick T, Wetmur James G, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M, Chen Jia

Abstract excerpt

Choline and betaine provide methyl groups for one-carbon metabolism. Humans obtain these nutrients from a wide range of foods. Betaine can also be synthesized endogenously from its precursor, choline. Although animal studies have implied a causal relationship between choline deficiency and carcin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19635752
DOI: 10.1096/fj.09-136507
PMCID: PMC2775010

Genes

BHMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19635752-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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High intakes of choline and betaine reduce breast cancer mortality in a population-based study.PMID 19635752Read ↗

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Association between Dietary Choline and Betaine Intake and 10.6-Year Cardiovascular Disease Outcomes and Mortality in AdultsSemantic proximity Read ↗

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.Semantic proximity Read ↗

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Common genetic polymorphisms affect the human requirement for the nutrient choline.Semantic proximity Read ↗

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