Article
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Sushma C, Prasad Shiva, Devi Rudrama, Murthy Sudha, Rao Ts, Naidu Ck
Abstract excerpt
BACKGROUND: Ras genes are thought to play an important role in human cancer since they have been found to be activated frequently in several types of tumors including breast cancer, where the overall incidence of K-RAS oncogene activation is 0-10%. Evaluation of K-RAS gene not only for mutational frequency but also for mutation types in this downstream signaling gene pathway is necessary to determine the...
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