H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.

doi:10.1038/modpathol.3800948

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Article

H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2007

Sathyan K M, Nalinakumari K R, Kannan S

Abstract excerpt

Activating mutations of the Ras is a moderately frequent event in oral carcinogenesis in Indian patients. Ras pathway has essential roles in regulation of various phases of the cell cycle, especially at G1 phase. Despite a large body of in vitro evidence, the multidimensional interaction between mutated Ras pathway and G1 cell cycle regulatory proteins in tumours in vivo is poorly determined. In the present...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma, Squamous Cell
Cell Cycle Proteins
DNA Mutational Analysis
Female
Genes, ras
Humans
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Male

Middle Aged

Mouth Neoplasms

Mutation

Polymorphism, Single-Stranded Conformational

Prognosis

Source

Open in PubMed

Identifiers

PMID: 17767136
DOI: 10.1038/modpathol.3800948

Genes

CDK4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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