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Article

H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2007

Sathyan K M, Nalinakumari K R, Kannan S

Abstract excerpt

Activating mutations of the Ras is a moderately frequent event in oral carcinogenesis in Indian patients. Ras pathway has essential roles in regulation of various phases of the cell cycle, especially at G1 phase. Despite a large body of in vitro evidence, the multidimensional interaction between mutated Ras pathway and G1 cell cycle regulatory proteins in tumours in vivo is poorly determined. In the present...

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Source

Identifiers

PMID: 17767136
DOI: 10.1038/modpathol.3800948

Genes

CDK4
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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