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Article

High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.

British journal of cancer - 1 Apr 1991

Saranath D, Chang S E, Bhoite L T, Panchal R G, Kerr I B, Mehta A R, Johnson N W, Deo M G

Abstract excerpt

57 primary tumour samples from Indian oral cancer patients with a 5-15 year tobacco chewing habit, were examined for mutational activation in codons 12, 13 and 61 of the H-ras, K-ras and N-ras oncogenes. The highly sensitive assay based on specific oligonucleotide hybridisation following in vitro amplification of unique sequences by polymerase chain reaction was employed. Mutations were detected in twenty (35%)...

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Identifiers

PMID: 2021541
DOI: 10.1038/bjc.1991.133
PMCID: PMC1972357

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