Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct conversion of human fibroblasts into functional osteoblasts by defined factors.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Yamamoto Kenta, Kishida Tsunao, Sato Yoshiki, Nishioka Keisuke, Ejima Akika, Fujiwara Hiroyoshi, Kubo Toshikazu, Yamamoto Toshiro, Kanamura Narisato, Mazda Osam

Abstract excerpt

Osteoblasts produce calcified bone matrix and contribute to bone formation and remodeling. In this study, we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some defined factors and culturing in osteogenic medium. Osteoblast-specific transcription factors, Runt-related transcription factor 2 (Runx2), and Osterix, in combination with Octamer-binding transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Regeneration
Share to Bone Remodeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcinosis

Share to Core Binding Factor Alpha 1 Subunit

Share to Gingiva

Share to Mice, Inbred NOD

Share to Octamer Transcription Factor-3

Share to Proto-Oncogene Proteins c-myc

Source

Open in PubMed Open full text

Identifiers

PMID: 25918395
DOI: 10.1073/pnas.1420713112
PMCID: PMC4434770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct conversion of human fibroblasts into functional osteoblasts by defined factors.PMID 25918395Read ↗

Direct Reprogramming of Fibroblasts to Osteoblasts: Techniques and MethodologiesSemantic proximity Read ↗

Transduction of Oct6 or Oct9 gene concomitant with Myc family gene induced osteoblast-like phenotypic conversion in normal human fibroblasts.Semantic proximity Read ↗

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein.Semantic proximity Read ↗

Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-β signal.Semantic proximity Read ↗

Direct conversion of human fibroblasts into osteoblasts and osteocytes with small molecules and a single factor, Runx2Semantic proximity Read ↗

Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individualsSemantic proximity Read ↗

Osteoblast differentiation in vitro and in vivo promoted by OsterixSemantic proximity Read ↗

Osteogenic Programming of Human Mesenchymal Stem Cells with Highly Efficient Intracellular Delivery of RUNX2Semantic proximity Read ↗

Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype.Semantic proximity Read ↗

Osteoblast-Specific Transcription Factor Osterix Increases Vitamin D Receptor Gene Expression in OsteoblastsSemantic proximity Read ↗

Isolation of Human Osteoblast Cells Capable for Mineralization and Synthetizing Bone-Related Proteins In Vitro from Adult BoneSemantic proximity Read ↗

Osteogenic Differentiation of Recombinant Adeno-Associated Virus 2-Transduced Murine Mesenchymal Stem Cells and Development of an Immunocompetent Mouse Model for Ex Vivo Osteoporosis Gene TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.