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Article

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein.

Journal of cellular biochemistry - 1 Nov 2016

Yamamoto Kenta, Sato Yoshiki, Honjo Kenichi, Ichioka Hiroaki, Oseko Fumishige, Sowa Yoshihiro, Yamamoto Toshiro, Kanamura Narisato, Kishida Tsunao, Mazda Osam

Abstract excerpt

Generation of osteoblasts from human somatic cells may be applicable in an effective transplantation therapy against bone diseases. Recently we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some transcription factor genes via retroviral vectors. However, retroviral vector-mediated transduction may potentially cause tumor formation from the infected cells, thus a...

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PMID: 26990860
DOI: 10.1002/jcb.25546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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