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Article

Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-β signal.

Scientific reports - 31 May 2018

Yamamoto Kenta, Kishida Tsunao, Nakai Kei, Sato Yoshiki, Kotani Shin-Ichiro, Nishizawa Yuta, Yamamoto Toshiro, Kanamura Narisato, Mazda Osam

Abstract excerpt

A procedure to generate functional osteoblasts from human somatic cells may pave the way to a novel and effective transplantation therapy in bone disorders. Here, we report that human fibroblasts were induced to show osteoblast phenotypes by culturing with ALK5 i II, which is a specific inhibitor for activin-like kinase 5 (ALK5) (tumor growth factor-β receptor 1 (TGF-β R1)). Cells cultured with ALK5 i II...

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Identifiers

PMID: 29855543
DOI: 10.1038/s41598-018-26745-2
PMCID: PMC5981640

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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