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Article

Osteoblast differentiation in vitro and in vivo promoted by Osterix

8 Jun 2007

Abstract excerpt

C3H10T1/2/Osx, a stably transfected cell line with Osterix (Osx), was produced and chondrocytic and osteoblastic differentiation were studied in vitro. Osx promoted osteoblastic lineage that was dexamethasone dependent. Furthermore, in vivo, Osx induced ectopic mineralization in a heterotopic mouse muscle model. Skeletogenesis involves a cascade of molecular activities sequentially performed by osteoblasts and...

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Identifiers

PMID: 17559111
DOI: 10.1002/jbm.a.31356

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