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Article

Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype.

Cell and tissue research - 1 Mar 2011

Wu Li-an, Feng Junsheng, Wang Lynn, Mu Yan-dong, Baker Andrew, Donly Kevin J, Harris Stephen E, MacDougall Mary, Chen Shuo

Abstract excerpt

Bone morphogenetic protein 2 (Bmp2) is essential for osteoblast differentiation and osteogenesis. Generation of floxed Bmp2 osteoblast cell lines is a valuable tool for studying the effects of Bmp2 on osteoblast differentiation and its signaling pathways during skeletal metabolism. Due to relatively limited sources of primary osteoblasts, we have developed cell lines that serve as good surrogate models for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21271257
DOI: 10.1007/s00441-010-1120-3
PMCID: PMC3050048

Genes

ATF4
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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