Article

Direct conversion of human fibroblasts into osteoblasts and osteocytes with small molecules and a single factor, Runx2

2017-04-14

Abstract excerpt

Human osteoblasts can be induced from somatic cells by introducing defined factors, however, the strategy limits cells therapeutic applications for its multi-factor and complicated genetic manipulations that may bring uncertainty into the genome. Another important cell type in bone metabolism, osteocytes, which play a central role in regulating the dynamic nature of bone in all its diverse functions, have not been...

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Literature Corpus work: b4e6010a-671f-5d03-b782-0c8e3b606547
DOI: 10.1101/127480

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