[IgVH mutation status in patients with chronic lymphocytic leukemia].

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Article

[IgVH mutation status in patients with chronic lymphocytic leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Mar 2008

Zhang Ya-Ping, Chen Li-Juan, Zheng Wen-Juan, Wu Yu-Jie, Qiu Hong-Xia, Qian Si-Xuan, Xu Wei, Li Jian-Yong

Abstract excerpt

OBJECTIVE: To evaluate the frequency and mutation status of IgVH gene expression in patients with chronic lymphocytic leukemia (CLL) in China. METHODS: IgVH mutation was detected by multiplex PCR and directly sequencing in 29 CLL patients. IgH somatic hypermutation and mutation site were analysed by IMGT/V-QUEST. RESULTS: Of 29 CLL patients, 21 had IgVH mutation (72%). The most frequently expressed VH gene family...

Topics

Adult
Aged
Aged, 80 and over
Chronic Disease
Female
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Mutation

Source

Open in PubMed

Identifiers

PMID: 18788614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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