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Article

Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.

Journal of medical virology - 1 Oct 2015

Kukimoto Iwao, Mori Seiichiro, Aoyama Satoru, Wakae Kousho, Muramatsu Masamichi, Kondo Kazunari

Abstract excerpt

Persistent infection with oncogenic human papillomavirus (HPV) causes cervical cancer. However, viral genetic changes during cervical carcinogenesis are not fully understood. Recent studies have revealed the presence of adenine/thymine-clustered hypermutation in the long control region of the HPV16 genome in cervical intraepithelial neoplasia (CIN) lesions, and suggested that apolipoprotein B mRNA editing enzyme,...

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PMID: 25914233
DOI: 10.1002/jmv.24215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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