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Article

Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.

PloS one - 1 Jan 2013

Kukimoto Iwao, Maehama Tomohiko, Sekizuka Tsuyoshi, Ogasawara Yumiko, Kondo Kazunari, Kusumoto-Matsuo Rika, Mori Seiichiro, Ishii Yoshiyuki, Takeuchi Takamasa, Yamaji Toshiyuki, Takeuchi Fumihiko, Hanada Kentaro, Kuroda Makoto

Abstract excerpt

Viral genetic diversity within infected cells or tissues, called viral quasispecies, has been mostly studied for RNA viruses, but has also been described among DNA viruses, including human papillomavirus type 16 (HPV16) present in cervical precancerous lesions. However, the extent of HPV genetic variation in cervical specimens, and its involvement in HPV-induced carcinogenesis, remains unclear. Here, we employ...

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Identifiers

PMID: 24236186
DOI: 10.1371/journal.pone.0080583
PMCID: PMC3827439

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Source receipt: pubmed, retrieved 7 Sept 2026.

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