Article
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance.
Nature communications - 14 Feb 2020
Zhu Bin, Xiao Yanzi, Yeager Meredith, Clifford Gary, Wentzensen Nicolas, Cullen Michael, Boland Joseph F, Bass Sara, Steinberg Mia K, Raine-Bennett Tina, Lee DongHyuk, Burk Robert D, Pinheiro Maisa, Song Lei, Dean Michael, Nelson Chase W, Burdett Laurie, Yu Kai, Roberson David, Lorey Thomas, Franceschi Silvia, Castle Philip E, Walker Joan, Zuna Rosemary, Schiffman Mark, Mirabello Lisa
Abstract excerpt
HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcinogenesis. We identify four de novo mutational signatures, one of which matches the COSMIC...
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