Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2.

Cerebellum (London, England) - 1 Dec 2015

Constantin Lena, Wainwright Brandon J

Abstract excerpt

MicroRNAs (miRNAs) are important regulators of cerebellar function and homeostasis. Their deregulation results in cerebellar neuronal degeneration and spinocerebellar ataxia type 1 and contributes to medulloblastoma. Canonical miRNA processing involves Dicer, which cleaves precursor miRNAs into mature double-stranded RNA duplexes. In order to address the role of miRNAs in cerebellar granule cell precursor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenesis
Share to Organ Size
Share to Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to Kruppel-Like Transcription Factors

Share to Neural Stem Cells

Share to Ribonuclease III

Share to Zinc Finger Protein Gli2

Source

Identifiers

PMID: 25910616
DOI: 10.1007/s12311-015-0672-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNAs Promote Granule Cell Expansion in the Cerebellum Through Gli2.PMID 25910616Read ↗

Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.Semantic proximity Read ↗

Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system.Semantic proximity Read ↗

MiR-30e and miR-181d control radial glia cell proliferation via HtrA1 modulation.Semantic proximity Read ↗

Understanding the role of dicer in astrocyte development.Semantic proximity Read ↗

Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development.Semantic proximity Read ↗

Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness.Semantic proximity Read ↗

Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.Semantic proximity Read ↗

Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm.Semantic proximity Read ↗

Multiple developmental programs are altered by loss of<i>Zic1</i>and<i>Zic4</i>to cause Dandy-Walker malformation cerebellar pathogenesisSemantic proximity Read ↗

Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex.Semantic proximity Read ↗

Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.Semantic proximity Read ↗

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.