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Article

Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.

Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2015

Chinn Gregory A, Hirokawa Karla E, Chuang Tony M, Urbina Cecilia, Patel Fenil, Fong Jeanette, Funatsu Nobuo, Monuki Edwin S

Abstract excerpt

Establishment of the corpus callosum involves coordination between callosal projection neurons and multiple midline structures, including the glial wedge (GW) rostrally and hippocampal commissure caudally. GW defects have been associated with agenesis of the corpus callosum (ACC). Here we show that conditional Lhx2 inactivation in cortical radial glia using Emx1-Cre or Nestin-Cre drivers results in ACC. The ACC...

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Identifiers

PMID: 24781987
DOI: 10.1093/cercor/bhu067
PMCID: PMC4537429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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