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Article

Understanding the role of dicer in astrocyte development.

PloS one - 1 Jan 2015

Howng Shen-Yi Bruce, Huang Yong, Ptáček Louis, Fu Ying-Hui

Abstract excerpt

The Dicer1 allele is used to show that microRNAs (miRNAs) play important roles in astrocyte development and functions. While it is known that astrocytes that lack miRNAs are dysregulated, the in vivo phenotypes of these astrocytes are not well understood. In this study, we use Aldh1l1-EGFP transgene, a marker of astrocytes, to characterize mouse models with conditional Dicer1 ablation (via either human or mouse...

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Identifiers

PMID: 25962146
DOI: 10.1371/journal.pone.0126667
PMCID: PMC4427179

Genes

GFAP

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