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Article

Multiple developmental programs are altered by loss of<i>Zic1</i>and<i>Zic4</i>to cause Dandy-Walker malformation cerebellar pathogenesis

10 Feb 2011

Abstract excerpt

Heterozygous deletions encompassing the ZIC1;ZIC4 locus have been identified in a subset of individuals with the common cerebellar birth defect Dandy-Walker malformation (DWM). Deletion of Zic1 and Zic4 in mice produces both cerebellar size and foliation defects similar to human DWM, confirming a requirement for these genes in cerebellar development and providing a model to delineate the developmental basis of...

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PMID: 21307096
DOI: 10.1242/dev.054114

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Multiple developmental programs are altered by loss of<i>Zic1</i>and<i>Zic4</i>to cause Dandy-Walker malformation cerebellar pathogenesisPMID 21307096Read ↗

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