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Article

p16INK4a in cellular senescence

17 Aug 2013

Abstract excerpt

A crucial mechanism in the establishment of cellular senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in H3K27me3 [2]. Upon senescence triggers, PRCs are displaced and the...

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Epigenetics and DNA Methylation
Genomics and Chromatin Dynamics
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23965734
DOI: 10.18632/aging.100592

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