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Article

Cellular senescence mediated by p16INK4A-coupled miRNA pathways

9 Nov 2013

Abstract excerpt

p16 is a key regulator of cellular senescence, yet the drivers of this stable state of proliferative arrest are not well understood. Here, we identify 22 senescence-associated microRNAs (SA-miRNAs) in normal human mammary epithelial cells. We show that SA-miRNAs-26b, 181a, 210 and 424 function in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm development (EED),...

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PMID: 24217920
DOI: 10.1093/nar/gkt1096

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