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An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence

8 Jul 2011

Abstract excerpt

BACKGROUND: Cellular senescence is an irreversible cell cycle arrest that normal cells undergo in response to progressive shortening of telomeres, changes in telomeric structure, oncogene activation or oxidative stress and acts as an important tumour suppressor mechanism. RESULTS: To identify the downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways crucial for mediating entry into...

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PMID: 21740549
DOI: 10.1186/1471-2164-12-355

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