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Article

Metastatic ER+ Breast Cancer: Mechanisms of Resistance and Future Therapeutic Approaches

11 Nov 2023

Abstract excerpt

Endocrine therapy is the main treatment for hormone receptor-positive (HR+) breast cancer. However, advanced tumors develop resistance to endocrine therapy, rendering it ineffective as the disease progresses. There are several molecular mechanisms of primary and secondary endocrine resistance. Resistance can develop due to either alteration of the estrogen receptor pathway (e.g., ESR1 mutations) or upstream...

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PMID: 38003387
DOI: 10.3390/ijms242216198

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